mercoledì 12 marzo 2008

Amyotrophic lateral sclerosis (ALS)

/s400/6.JPG" border="0" alt=""id="BLOGGER_PHOTO_ID_5418947089264869906" />


Figure 1 and Figure 2: Coronal T2-weighted images obtained at the level of the internal capsules. There is continuous linear abnormal high signal intensity within the bilateral hemispheric white matter extending through the corona radiata, posterior limbs of the internal capsules and cerebral peduncles.
Figure 3: Axial FLAIR image at the level of the cerebral hemispheric subcortical white matter. There is bilaterally symmetric high signal intensity abnormality in the white matter fibers of the centrum semiovale.
Figure 4 and Figure 5: Axial FLAIR images at the level of the posterior limbs of the internal capsules. There are bilaterally symmetric, well-circumscribed areas of high signal intensity involving the corticospinal tracts which, at this level, are located in the posterior aspect of the posterior limbs of the internal capsules.
Figure 6: Axial FLAIR image the level of the anterior commisure. Bilateral, well-circumscribed areas of FLAIR high signal intensity localize to the corticospinal tracts are demonstrated.
Figure 7: Axial proton density weighted image at the level of the posterior limbs of the internal capsules. Bilateral, well-circumscribed areas of PD high signal intensity localized to the corticospinal tracts are demonstrated.
Figure 8: Axial proton density weighted image at the level of the cerebral peduncles. There is extension of high signal intensity into the cerebral peduncles along the corticospinal tracts.

The corresponding T1-weighted images demonstrated normal findings. The MRI images of the cervical spine demonstrated normal findings.

Diagnosis: Amyotrophic Lateral Sclerosis (ALS), also known as Lou Gehrig's disease

Amyotrophic lateral sclerosis is a devastating, progressive neurodegenerative disorder that demonstrates both upper and lower motor neuron symptoms. The pathological hallmark of ALS is the degeneration of neurons in the motor cortex and loss of anterior horn cells in the spinal cord with astrocytic gliosis. The surviving motor neurons are shrunken.

Clinically, the symptoms are primarily those of weakness, which may start in the hands or legs or the disease can be manifested by slurred speech and dysphagia. There should be no autonomic, sensory or cognitive involvement.

The exact cause of the disease is not well known. Onset is in the middle and late adult years. About 5-10% of cases are familial. The rest are sporadic. Amyotrophic lateral sclerosis demonstrates a male predilection with a male:female ratio of 1.5:1 5.

Typical MR imaging findings include high signal intensity involving the corticospinal tracts on T2, FLAIR and proton density weighted imaging. This abnormal signal intensity may be seen extending from the hemispheric white matter, through the corona radiata, through the caudal aspect of the posterior limbs of the internal capsules, and finally into the ventral aspect of the brain stem. The signal abnormality appears symmetric and well circumscribed. Occasionally signal abnormality is seen extending into the anterolateral column of the spinal cord. Involvement of the corpus callosum has also been reported.

Care should be taken when evaluating the corticospinal tracts on T2-weighted images because about 50% of normal patients display symmetric foci of high signal intensity that are isointense to gray matter on T2-weighted images within the caudal one-third of the posterior limbs of the internal capsules. However, in normal patients, the signal should never extend above the internal capsule to the corona radiata. Proton density imaging is more specific in evaluating for abnormal signal since in normal patients, the corticospinal tracts are isointense to the remainder of the internal capsule and therefore any abnormal signal on PD should be considered pathological.

The disease is progressive; the mean duration of survival is three to five years.

Positive MR findings correlate with average or rapid progression of the disease, while negative MR findings appear to correlate with slower disease progression.

2 commenti:

  1. Hi I was diagnosed March 2017 but was running around from doctor to doctor before I finally get a result that I was free from MND ALS. Mine started on top and progressed into bottom I could walk very little but need assistance as I have no balance. It is sad all time that we thought this disease has no cure with all the technology we have while there re some formulas at there that can relief all symptoms and get this of ALS  . I’m passing this info to anyone at there because totalcureherbsfoundation com has the right cure and caregiver this disease ….I took various supplements, medicine prescribed by neurologist,massage and physiotherapy still the disease is was progressing very fast until the the ALS formula from that company .

  2. All thanks to this great herbal doctor who cured me from (LUPUS DISEASE) his name is dr imoloa.  I suffered lupus disease for over 8 years with pains like: joints, Skin rash,  Pain in the chest,  swollen joints and many more.  The anti-inflammatory drugs couldn’t cure me, until I read about his recommendation. 2 months ago, I contacted him through his email address. . and he sent me the herbal treatment through DHL courier service and he instructed me on how to drink it for good two weeks. after then,  And I was confirmed cured and free at the hospital after taken his powerful herbal medications You too can be cured with it if interested, he also uses his powerful herbal healing medicine to cure disease like: parkison disease, vaginal cancer, epilepsy,  Anxiety Disorders, Autoimmune Disease,  Back Pain,  Back Sprain,   Bipolar Disorder,  Brain Tumour,  Malignant,  Bruxism, Bulimia,  Cervical Disk Disease, cardiovascular disease, Neoplasms,  chronic respiratory disease,  mental and behavioural disorder,  Cystic  Fibrosis,  Hypertension, Diabetes, asthma,  Inflammatory autoimmune-mediated arthritis.  chronic kidney disease, inflammatory joint disease, back pain,  impotence,  feta  alcohol spectrum,  Dysthymic Disorder,   Eczema, skin cancer,  tuberculosis,  Chronic Fatigue Syndrome, constipation, inflammatory bowel  disease, bone cancer, lungs cancer,  mouth ulcer,  mouth cancer, body pain, fever, hepatitis A.B.C.,   syphilis,  diarrhea,  HIV/AIDS,  Huntington's Disease,  back acne,  Chronic renal failure,   addison disease,  Chronic Pain,   Crohn's  Disease,   Cystic Fibrosis,  Fibromyalgia,   Inflammatory Bowel Disease,  fungal  nail disease, Lyme Disease, Celia disease, Lymphoma, Major  Depression,  Malignant Melanoma,   Mania,  Melorheostosis,   Meniere's  Disease,  Mucopolysaccharidosis , Multiple Sclerosis,  Muscular  Dystrophy,  Rheumatoid Arthritis, Alzheimer's Disease      Contacts him today  and get permanently cure. contact him via... email-  /whatssapp-+2347081986098.