lunedì 1 giugno 2009

Creutzfeldt-Jakob Disease (CJD)


Noncontrasted head CT shows subtle basal ganglia hypo attenuation bilaterally and enlarged bilateral extra-axial fluid spaces. Contrast enhanced brain MR demonstrates increased signal on FLAIR and T2-weighted sequences with corresponding restricted diffusion bilaterally in the caudate nuclei, globi pallidi, posterior thalami, hippocampi and in the cortex of the bilateral occipital-parietal, right frontal and temporal lobes without enhancement. Brain MR 4 weeks later shows persistence of restricted diffusion in the same areas of the brain.

Differential diagnosis:
- Mitochondrial disorder like MELAS or Leigh syndrome
- Creutzfeldt-Jakob Disease
- Viral encephalitis
- Carbon monoxide poisoning

Diagnosis: Creutzfeldt-Jakob disease.

Key points

CJD is one of the neurodegenerative disorders called prion diseases (also known as spongiform encephalopathies), which are uniformly fatal.
90% of cases are sporadic; the other 10% are familial.
CJD is characterized clinically by rapid and progressive dementia, other neurologic abnormalities, and ultimately death.
There is no cure.
WHO criteria for diagnosis requires tissue for definite cases or typical clinical, lab or EEG findings for probable or possible cases; imaging findings are not included.
Typical MR findings of sporadic CJD include increased signal in grey matter on T2-weighted, FLAIR, proton density, and diffusion-weighted (DW) images.
It is more often bilateral.
The caudate nuclei and putamina are usually more affected than the thalami and cerebral cortex.
Diffusion-weighted images are the most sensitive sequence for early, typical signal changes, followed by FLAIR sequences.
Eventually, brain atrophy is a characteristic feature of CJD.
Persistent restricted diffusion, over weeks or months, in typical areas of the brain is virtually diagnostic of CJD.
Acute diffusion restriction in the basal ganglia is seen with carbon monoxide poisoning, but it does not persist and preferentially involves the globus pallidus.

2 commenti:

  1. I was diagnosed of Herpes 2 years ago and I have tried all possible means to get the cure but all to no avail, until I saw a post in a health forum about a Herbal Doctor(Dr Akhigbe) who prepares herbal medicine to cure all kind of diseases including Herpes, at first i doubted, if it was real but decided to give him a trial, when I contacted Dr Akhigbe through his Email: he guided me and prepared a herbal medicine and sent it to me via courier Delivery service,when I received the package (herbal medicine) He gave me instructions on how to consume it,I started using it as instructed and I stopped getting outbreaks and the sores started vanishing, could you believe I was cured of this deadly virus within two to three weeks and notices changes in my body. Days of using this REMEDY,couldn't believe the healing at first until I see it as my HERPES  get cleared like magic Dr Akhigbe also use his herbal medicine to cure diseases like, HIV, HERPES, CANCER, ALS, CHRONIC DISEASE, HEART DISEASE, LUPUS, ASTHMA,  DIABETES  HEPATITIS A AND B.ECZEMA, BACK PAIN, EXTERNAL INFECTION ,ASTHMA, EPILEPSY,STROKE,KIDNEY DISEASE,ACME. etc Contact this great herbal Doctor today the father of herbal root cure. via Email: or whatsapp him +2348142454860 and get cured permanently He is